Many people who receive antidepressant treatment for their depression do not get an adequate response to the medicines they are taking. If someone has taken, or is currently taking, two or more antidepressants that are not working, this is sometimes referred to as treatment-resistant depression or TRD.

The Compass Pathfinder studies are looking into a potential new approach for people with TRD using an investigational medicine, called psilocybin therapy or psilocybin treatment, given with psychological support. The study is suitable for people who have been diagnosed with major depression and are currently experiencing a recurrent or single episode of depression and have not responded to antidepressant treatment.

You may be eligible to participate in the Compass Pathfinder studies if you:
     • Are 18 years of age or older
     • Have ever been diagnosed with depression
     • Are experiencing treatment-resistant depression, defined as trying 2 or more antidepressant medications for your depression but still                      experiencing symptoms of depression
     • Meet additional study criteria


If you are interested in learning more about the Compass Pathfinder studies, please contact us for an informal chat at 646-351-0220 or simona@spectrumneuroscience.org. We will ask you some brief questions and provide additional information about the study.
Expressing an interest does not oblige you in any way to take part in the studies. So please, do get in touch if you want to find out more.